Comorbidity of chronic somatic diseases in patients with psychotic disorders and their influence on 4-year outcomes of integrated care treatment (ACCESS II study)

Abstract Background People with psychotic disorders fulfilling criteria of a severe and persistent mental illness (SPMI) display a high risk of somatic comorbidity (SC). Methods ACCESS II is a prospective, long-term study examining the effectiveness of Integrated Care for people with psychotic disorders fulfilling SPMI criteria. Chronic comorbid somatic disorders were systematically assessed according to ICD-10-GM criteria. Patients treated for ≥ 4 years in ACCESS were categorized as early psychosis (treatment: ≤ 2 years) or non-early psychosis (treatment: > 2 years) patients. Results Of 187 patients treated in ACCESS for ≥ 4 years (mean age = 41.8 years, males = 44.4%), 145 (77.5%) had SC, (mean = 2.1 ± 2.1). Overall, 55 different diseases from 15 different ICD-10-GM disease areas were identified. Prevalence of ≥ 1 SC (p = 0.09) and specific types of SC (p = 0.08–1.00) did not differ between early and non-early psychosis patients, but non-early psychosis patients had a higher mean number of SC (2.3 ± 2.2 vs. 1.3 ± 1.3, p = 0.002). SC patients had higher rates of comorbid mental disorders (93% vs. 81%, p = 0.002), specifically posttraumatic stress disorder (23% vs. 7%, p = 0.002), and suicide attempts (43% vs. 19%, p  Conclusions SC is frequent in patients with severe psychotic disorders, even in the early psychosis phase. The magnitude of the problem underlines the need for regular screening, comprehensive assessment, preventive pharmacotherapy, and targeted SC management.