EFEK PEMBERIAN SPILANTHES ACMELLA DAN LATIHAN FISIK TERHADAP JUMLAH SEL OSTEOBLAS FEMUR MENCIT YANG DIINDUKSI DEKSAMETASON EFFECT OF SPILANTHES ACMELLA AND EXERCISE ON OSTEOBLAST CELLS FEMUR IN MICE DEXAMETHASONE INDUCED

Study was conducted to analyse the anti-osteoporosis effect of Spilanthes acmella plant in vivo on osteoblast cell trabecular bone of femur male mice with dexamethasone- induced osteoporosis. This study using a post test control group design, 60 male healthy mice (>5 months old) were randomizely devided into 10 groups, there are healthy control group (without induction dexamethaxone), and osteoporosis groups (induction with dexamethaxone). The positive control receive suspension alendronat suspension and the exercise group walking using mice treadmill 10m/minute, 5-12 minutes 3 times a week,the combination group of 70% extract ethanol and exercise, the butanol, hexane, etil asetat and water fraction group. The study conducted for 4 weeks. Glucocorticoid-induced osteoporosis is leading cause of secondary osteoporosis and an increase in fracture risk. There were clinical evidence suggest a role for phytoestrogen in the treatment of post-menopausal osteoporosis. Spilanthes acmella, or already