M1381 Use and Helpfulness of Mechanism-Targeted Medical Pain Therapies in Chronic Pancreatitis

AIM: SF-36 Health Survey is a generic questionnaire designed as an assessment method of health status, using 36 questions that are grouped in eight scales: physical functioning (PF), role physical functioning (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional functioning (RE), and mental health (MH). This study was designed to examine the quality of life (QOL) in patients with chronic pancreatitis (CP) of varying severity, and to determine the factors associated with poor physical and mental health. Material and method: We studied 104 pacients, (93.2% male and 6.8% female) from a tertiary care gastroenterology clinic. The diagnosis of chronic pancreatitis was made by a combination of morphologic, functional, and clinical findings. Data were obtained either by face-to-face interview (31%) or by telephone (69%). Results: The scale scores of PF, RP, BP, GH, VT, SF, RE, and MH were as follows: 58.7, 65.1, 77.6, 65.7, 54.4, 53.6, 69.4, and 66.9. When compared to the general population (values of mean SF-36 scores published 8 years ago by The National Institute of Statistics), all domains of health-related quality of life were reduced in CP, mainly in witch concernes PF (p=0.08), symptoms' severity (p=0.005) and the cognitive function impairment (p=0.004). Furthermore, regarding the severity of CP assessed by imagistic (CT, EUS and ERCP) and functional means (fecal elastase test), the 64 (61,7%) patiens meeting the stage III Cambridge criteria scored significantly worse then those in stage II (n=28, 27.1%); or I (n=12,11.1%) (p<0.005). Out of the various variables that we considered as possible factors related to CP (pancreatic calcifications, Wirsung duct dilatation, pseudocysts, pancreatic insufficiency, diabetes), only pain significantly impaired all eight domains (ANOVA, p< 0.0005 for all scales). Regarding the changes in pancreatic morphology, main pancreatic duct dilatation was the element that influenced the most QOL in CP. Patients presenting Between clinical variables patients presenting diabetes mellitus, pancreatic insufficiency and BMI < 19 scored worse mainly for physical domains Conclusion: Patients with CP presented an impaired QOLwitch wasmore important in the physical component than in the mental component. In our study, pain was the clinical element that impaired all 8 domain of SF-36, whereas pancreatic morphological changes, and other clinical elements influenced only some of these domains.