Перспективы использования новых соединений класса тиосемикарбазонов с целью создания лекарственных препаратов, обладающих противотуберкулезной активностью

The article deals with the results of experimental study of anti tuberculosis activity of new salt tiosemicarbazone (Phs-205) in comparison with substance of perhloson (perchlorate-4-tioureidoiminometyl-pyridinium). The model of generalized tuberculosis of mice was used to evaluate anti tuberculosis activity of Phs-205 in dosage of 10, 20 and 30 mg/kg and perhloson in dosage of 20 mg/kg according pathomorphological and microbiological criteria. It is established that Phs-205 in dosage of 30 mg/kg has the most expressed protective and therapeutic effect under experimental tuberculosis caused by mycobacterium of tuberculosis of human type H37Rv. The results of biochemical study testify the more expressed toxic effect of perhloson upon indicators of protein and lipid metabolism.