Evaluation of the impact of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives on lepodova effects in the test of suspension by the tail

A series of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives exhibited high antidepressant and adaptogen activities. We now report a more detailed analysis of the effects of those substances on dopamine metabolism. For that purpose, we decided to unite two techniques: evaluation of the impact of compounds with antidepressant activity on levodopa effects and the test of suspension by the tail. Caffeine-sodium benzoate, amitriptyline, and fluoxetine were chosen as references.