Amyloid-β peptides, Alzheimer's disease and the blood-brain barrier.
2013
Ever since amyloid-β (Aβ) peptides were first identified in cerebral plaques in patients with Alzheimer’s disease
(AD), much research work has focused on the complex mechanisms through which these peptides are synthesized,
transported and degraded. Although new information emerges on a regular basis, we consider that the importance of the
blood-brain barrier (BBB) in the pathogenesis of AD has been underestimated. In fact, there are a number of obstacles that
make it difficult to convince specialists in AD that the BBB indeed plays a key role in this disease: these include the complex
physiology of the BBB and the technical difficulty of studying the barrier in vivo and reproducing its main properties
in vitro. With these considerations in mind, the present review sets out summarize our current knowledge about the physiology
of the BBB and describe recent research findings on the barrier's role in Aβ peptide proteostasis and thus in the
mechanism of AD.
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