47 Correlation of eeg-based brain resuscitation index(EBRI) and end TIDAL CO2 in porcine cardiac arrest model: ebri-one trial

Aim Evaluation and monitoring of brain viability is important during resuscitation of cardiac arrest. We developed non-invasive EEG-based brain resuscitation index (EBRI) and evaluated correlation EBRI and end-tidal CO2(ETCO2). Method A randomised crossover animal experimental study using porcine cardiac arrest model was designed. After 1 min of untreated ventricular fibrillation, alternation of high quality CPR (compression depth 5 cm and compression rate 100/min) and low quality CPR (compression depth 3 cm and compression rate 60/min) was performed for every 50 s in 10 phases. EBRI was calculated from selected single EEG channel which have the lowest noise. Mixed model analysis was conducted to compare the differences of haemodynamic parameters, ETCO2 and EBRI between high quality CPR period and low quality CPR period. Pearson’s correlation coefficient was calculated to assess correlation between EBRI and ETCO2. Results Experiment was performed in four female porcine (44.6±2.8 kg). EBRI and EtCO2 was obtained according to quality of CPR received. Delta ETCO2-based EBRI obtained during high quality CPR was significantly higher than delta EBRI of lower quality CPR (HQ : Median 0.1, (0.0–0.2), LQ: Median −0.1 (−0.2–0.0, p≤0.01). EBRI had statistically moderate positive correlation with ETCO2 (r=0.51). Conclusion In porcine cardiac arrest model, EEG-based Brain Resuscitation Index was successfully obtained during resuscitation and had statistically moderate correlation with ETCO2. Conflict of interest None Funding None