[Effect of Runing II on expression of vascular endothelial growth factor in transplanted tumor of mammary cancer MA-891 in TA2 mice].

To study the effect of Runing Ⅱon expression of vascular endothelial growth factor (VEGF) in transplanted tumor of mammary cancer MA-891 in TA2 mice. Methods The MA-981 mice mammary cancer cell cultivated in vivo was inoculated into the right axilla subcutaneously of TA2 mice to establish the transplanted tumor model, which were treated with Runing Ⅱ. Results Runing Ⅱ could inhibit the growth of transplanted tumor and the occurrence of lung metastasis (P0.05), reduce the expression of VEGF protein and mRNA in tumor tissue (P0.05). Conclusion Runing Ⅱ could reduce the expression of VEGF protein and mRNA, hence to inhibit the growth of tumor and lung metastasis.