Minor Metabolites from the Ascidian Stolonica socialis and Cytotoxicity of Stolonoxides
2000
Abstract Bioassay guided isolation of the metabolites of the ascidian Stolonica socialis from Tarifa Island (Cadiz, Spain) led to a series of cyclic peroxides. A 9:1 mixture of stolonoxide A and the new stolonoxide B, a 6:4 mixture of their corresponding sodium salts, and a minor 6:4 mixture of the new stolonoxides C and D obtained as their sodium salts. Their structures were established by spectroscopic study of both the natural mixtures, whose constituents differ in the geometry of a double bond, and the corresponding methyl esters. The strong cytotoxicity exhibited by the stolonoxides against five tumor cell lines is presented and discussed.
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