Treatment of Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for phlebitis caused by amiodarone extravasation: an animal study

Objective To evaluate the effects of Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for phlebitis caused by amiodarone extravasation in an animal study. Methods A total of 15 adult rabbits were selected in March 2017. We built a model according to amiodarone damage. All of the rabbits were numbered by weight from light to heavy and divided into five groups with the random number table including group A (model group) , group B (group with 50% magnesium sulfate for external application) , group C (with Phentolamine for external application) , group D (with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for external application) and group E (Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for external application) . We compared the differences in naked eye observation, pathological observation and immunohistochemistry among five groups and compared the differences of group A with other four groups. Results There were no significant differences in effects of symptom observation among five groups on the first day after different treatments for amiodarone extravasation (P>0.05) . The differences in treatment effects were significant among five groups on the second and third day after treatments (P 0.05) . Conclusions The Phentolamine combined with Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel for phlebitis caused by amiodarone extravasation has obvious effects in an animal study. Key words: Phentolamine; Lincomycin Hydrochloride and Lidocaine Hydrochloride Gel; Infusion extravasation; Amiodarone