FRI0147 Analysis of radiographic joint destruction in the patients with rheumatoid arthritis who have withdrawn, spaced and continued biologics after achieving sustained remission from local biologics registry

Background Increasing of remission reached by biologics agents in early and established RA patients1, 2. Data on withdrawn, spacing or reducing of biologics (BIO) medication after sustained remission are limited3,4. After withdrawn, spacing or reducing, it is less known to be influenced the radiographic destruction of the joints. Objectives To retrospectively analyse the joint destruction using modified Total Sharp Score (mTSS) in RA patients in sustained remission, either withdrawing, spacing and continuing BIO. Methods Local prefectural (ZAO) registry which is open-labelled BIO cohort study has registered 356 RA patients. RA Patients were enrolled into this study if they maintained in DAS remission (DAS28-ESR Results 40 RA patients (32 female) using BIO was fulfilled in the criteria of this study in ZAO registry. Of 40 RA Patients, 10 has withdrawn BIO, 15 has spaced and 15 has continued it after maintain DAS remission more than one year. Mean age was 43, 55, 54 year-old, mean RA affiliation 4.6, 15.3, 9.1 years before BIO and mean duration of remission 6.2, 7.6, 7 years, mean dosage of MTX and PSL was 7.7, 6, 5 mg/week and 1.1, 3, 4 mg/day, respectively. ΔmTSS1 and ΔmTSS2 was +2.4 and+4.5 in withdrawn group,+3.6 and+0.9 in spacing group,+0.2 and −1.4 in continuing group, respectively (figure 1, p Conclusions Several studies reported the potential of BIO withdrawing, spacing or reducing in the patients with RA who reached remission3), 5). All cases in spacing and withdrawing group have shown DAS28–4ESR References [1] O’Dell JR. Arthritis Rheum2002;46:283–85. [2] Smolen JS, et al. Ann Rheum Dis2017;76:960–77. [3] Tanaka Y, et al: Ann Rheum Dis2015;74:389–95. [4] Takeuchi T, et al: Ann Rheum Dis2014;73:536–43. [5] Fautrel B, et al. Ann Rheum Dis2016;75:59–67. Acknowledgements Disclosure of Interest None declared