Retraction Note to: Mitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virus.
2018
To establish an association between mitochondrial dysfunction and
apoptosis following infectious bronchitis virus (IBV) infection, HD11 avian
macrophage cells were infected with the Massachusetts 41 (M41) strain. Our results
show that the M41 strain of IBV induced cytopathic effects followed by the release
of new viral particles. Elevated numbers of apoptotic cells were observed at 24, 48
and 72 h post-infection (p.i.). Viral infection was associated with mitochondrial
membrane depolarization and reactive oxygen species (ROS) production at all of the
examined timepoints p.i. In summary, IBV M41 replication in infected HD11
macrophages seems to induce mitochondrial bioenergy failure, acting as a respiratory
chain uncoupler, without compromising viral replication.
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