Abstract WMP15: Serial Aspects in the Dawn Trial: Infarct Evolution and Clinical Impact

Background: The impact of baseline ischemia on Aspects and evolution over 24 hours may be distinct in the late thrombectomy time window recently established by dawn. Aspects may enable practical triage of thrombectomy candidates more than 6 hours after onset. Methods: The dawn Imaging Core Lab independently scored Aspects at baseline and 24 hours. Descriptive statistics characterized Aspects on CT or MRI at baseline and 24 hours, delineating serial ASPECTS change or infarct evolution over 24 hours and analyzing associations with clinical variables, treatment arm and clinical outcomes. Results: 193 DAWN subjects (mean age 70.2 ± 13.7 yrs; 56% female; baseline NIHSS median 17 (14, 21) had core lab adjudicated Aspects at both baseline and 24 hours. Baseline Aspects was median 8.0 (3-10), with 89/193 (46.1%) between 0-7 and 104/193 (53.9%) between 8-10. 24-hour ASPECTS was median 6.0 (0-9), with serial ASPECTS change or infarct evolution of median -1, ranging from -8 to 0. Multivariate logistic regression sho...