Non-invasive Vocal Biomarker is Associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection.
2021
Objective To investigate the association of voice analysis with SARS-CoV-2 infection. Patients and methods A vocal biomarker, a unitless scalar with a value between 0-1, was developed based on 434 voice samples. The biomarker training was followed by a prospective, multi-center, observational study. All subjects were tested for SARS-CoV-2, had their voice recorded to a smartphone application and gave their informed consent to participate in the study. The association of SARS-CoV-2 infection with the vocal biomarker was evaluated. Results Final study population included 80 subjects with a median age of 29 [23-36], of whom 68% were men. Forty patients were positive for SARS-CoV-2. Infected patients were 12 times more likely to report at least one symptom (odds ratio 11.8, p Conclusion Voice analysis is associated with SARS-CoV-2 status and holds the potential to improve the accuracy of self-reported symptom-based screening tools. This pilot study suggests a possible role for vocal biomarkers in screening for SARS-CoV-2 infected subjects.
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