A phase I clinical and pharmacokinetic study of flavopiridol administered concurrently with 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) for advanced solid tumors

Raymond D. Meng,Richard D. Carvajal,Archie Tse,M. A. Shah,Heather J. Dials,D. Brukner,Eileen Mary OReilly,David P. Kelsen,G.K. Schwartz

A phase I clinical and pharmacokinetic study of flavopiridol administered concurrently with 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) for advanced solid tumors

2006

Raymond D. Meng
Richard D. Carvajal
Archie Tse
M. A. Shah
Heather J. Dials
D. Brukner
Eileen Mary OReilly
David P. Kelsen
G.K. Schwartz

13515 Background: Flavopiridol, a potent cyclin-dependent kinase inhibitor, enhances oxaliplatin-induced apoptosis in HCT116 colon cancer cells in vitro, especially with concurrent therapy. Signifi...

Keywords:

Cancer research
Fluorouracil
Oxaliplatin
FOLFOX
Medicine
Pharmacokinetics
In vitro
Pathology
Apoptosis
Colorectal cancer
Kinase

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