NR2B-N-Methyl-D-Aspartate Receptors Contribute to Network Asynchrony and Loss of Long-Term Potentiation Following Mild Mechanical Injury In Vitro

Abstract : To understand how mechanical injury affects neural circuits, we (1) built a multi-scale stochastic integrate-and-fire model of network activity, (2) simulated an injured network, (3) predicted an important role for the NR2B-NMDA receptor in mediating network asynchrony, and 4) tested our predictions using in vitro stretch injury