Atorvastatin donor pretreatment prevents ischemia/ reperfusion injury in renal transplantation in rats : Possible role for aldose-reductase inhibition

Background.The aim of the present study was to evaluate the effect of donor pretreatment with atorvastatin on ischemia/reperfusion (I/R) injury in renal transplantation in rats.Methods.Donor rats were pretreated orally with atorvastatin or vehicle 2 days prior to explantation. Kidneys were stored fo