The ability of the mouse lymphoma TK assay to detect aneugens

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s of the United Kingdom environmental mutagen society 23(rd) annual general meeting, June 23-25, university of Ulster, Coleraine, Northern Ireland, UK. Mutagenesis, 14, 639–656. 7. Wang, J., Sawyer, J. R., Chen, L., Chen, T., Honma, M., Mei, N. and Moore, M. M. (2009) The mouse lymphoma assay detects recombination, deletion, and aneuploidy. Toxicol. Sci., 109, 96–105. 8. Evans, H. H., Mencl, J., Horng, M.-F., Ricanati, M., Sanchez, C. and Hozier, J. (1986) Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions. Proc. Natl Acad. Sci. U S A, 83, 4379–4383. 9. Liechty, M. C., Scalzi, J. M., Sims, K. R., Crosby, H., Jr., Spencer, D. L., Davis, L. M., Caspary, W. J. and Hozier, J. C. (1998) Analysis of large and small colony L5178Y tk-/mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination. Mutagenesis, 13, 461–474. 10. Fellows, M., Doherty, A., Hayes, J., Thompson, A. and O’Donovan, M. R. (2005) In the mouse lymphoma Tk assay, are Tk / mutant clones formed following treatment with the aneugen Carbendazim monosomic for chromosome 11? Abstracts of the 28th Annual Meeting of the United Kingdom Environmental Mutagen Society, August 3–5, at the University of Bradford, UK. Mutagenesis, 20, 469–488. 11. de Nooij-van Dalen, A. G., van Buuren-van Seggelen, V. H. A., Lohman, P. H. M. and Giphart-Gassle, M. (1998) Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro. Genes Chromosomes Cancer, 21, 30–38. 12. Wijnhoven, S. W., Sonneveld, E., Kool, H. J., van Teijlingen, C. M. and Vrieling, H. (2003) Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes. Carcinogenesis, 24, 139–144. 13. Kirsch-Volders, M., Vanhauwaert, A., Eichenlaub-Ritter, U. and Decordier, I. (2003) Indirect mechanisms of genotoxicity. Toxicol. Lett., 140–141, 63–74. 14. Schiff, P. B., Fant, J. and Horwitz, S. B. (1979) Promotion of microtubule assembly in vitro by taxol. Nature, 277, 665–667. 15. Faust, J. B. and Salmon, A. (2003) Evidence on the Carcinogenicty of Chloral hydrate (2003 Update). Reproductive and Cancer Hazard Assessment Section, Office of environmental health Hazard assessment, California environmental Protection Agency, http://oehha.ca.gov/prop65/ hazard_ident/pdf_zip/chloralhyDhid.pdf. (accessed March 22, 2011). 16. Diguiseppi, J., Gawdi, G. M. and Herman, B. (1987) Chloral hydrate disrupts mitosis by increasing intracellular free calcium. J. Cell Sci., 88, 603–612. 17. Schuler, M., Muehlbauer, P., Guzzie, P. and Eastmond, D. A. (1999) Noscapine hydrochloride disrupts the mitotic spindle in mammalian cells and induces aneuploidy as well as polyploidy in cultured human lymphocytes. Mutagenesis, 14, 51–56. 18. Aneja, R., Dhiman, N., Idnani, J., Awasthi, A., Arora, S. K., Chandra, R. and Joshi, H. C. (2007) Preclinical pharmacokinetics of bioavailability of noscapine, a tubulin-binding anticancer agent. Cancer Chemother. Pharmacol., 60, 831–839. 19. Andersson, L. C., Lehto, V. P., Stenman, S., Badley, R. A. and Virtanen, I. (1981) Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation. Nature, 291, 247–248. 20. Parry, J. M. and Sors, A. (1993) The detection and assessment of aneugenic potential of environmental chemicals: the European Community Aneu- ploidy Project. Mutat. Res., 287, 3–15. 21. Wallin, M., Friden, B. and Billger, M. (1988) Studies of the interaction of chemicals with microtubule assembly in vitro can be used as an assay for detection of cytotoxic chemicals and possible inducers of aneuploidy. Mutat. Res., 201, 303–311. 22. Jordan, M. A. and Wilson, L. (2004) Microtubules as a target for anticancer drugs. Nat. Rev. Cancer, 4, 253–265. 23. Gudi, R., Xu, J. and Thilagar, A. (1992) Assessment of the in vivo aneuploidy/micronucleus assay in mouse bone marrow cells with 16 chemicals. Environ. Mol. Mutagen., 20, 106–116. 24. Hozier, J., Sawyer, J., Moore, M. M., Howard, B. and Clive, D. (1981) Cytogenetic analysis of the L5178Y/TKþ/leads to TK-/mouse lymphoma mutagenesis assay system. Mutat. Res., 84, 169–181. 25. Sawyer, J., Moore, M. M., Clive, C. and Hozier, J. (1985) Cytogenetic characterization of the L5178Y TKþ/ 3.7.2C mouse lymphoma cell line. Mutat. Res., 147, 243–253. 26. Clive, D., Flamm, W. G., Machesko, M. R. and Bernheim, N. J. (1972) A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutat. Res., 16, 77–87. Fig. 7. Chromosome 11 showing centromere size in clone with LOH at all markers. Cell from a colony treated with 0.015 lmol/l taxol showing size difference in centromeres of chromosome 11 (highlighted in green in the left image and in pink in the right inverted image). M. D. Fellows et al.
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