Effects of contrast medium on left ventricular pressure and volume with emphasis on coronary artery disease

Summary Forty-one patients had left ventricular angiographyrepeated 3 minutes after an initial study in order to evaluate the effect of angiographic contrast medium on left ventricular end-diastolic pressure (EDP) and volume (EDV). Seven patients had no evidence of heart disease (normal group) and 34 patients had coronary artery disease. Single-vessel disease was present in 10, double-vessel disease in 10, and triple-vessel disease in 14 patients. Seven other patients with radiopaque epicardial clips previously attached to the left ventricle underwent cinefluorographic studies to determine end-diastolic intraclip distance at various intervals after a left ventricular angiogram. In all the groups studied there was a significantincrease (p