Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats

AbstractContext: The leaf of Careya arborea Roxb. (Lecthidaceae) has been advocated in Ayurveda for the treatment of various disorders, including ulcers, healing of wounds and several skin diseases.Objective: The 70% ethanol (EtOH) extract of C. arborea leaves (CALE) was investigated for its gastroprotective effect in different gastric ulcer models.Materials and methods: CALE (100, 200, and 400 mg/kg body weight) was administered orally, twice daily for 5 d, for preventing aspirin (ASP)-, EtOH-, pylorus ligation (PL)-, and cold restraint stress (CRS)-induced ulcer in rats. The status of the antioxidant enzymes in CRS-induced ulcers, H+K+ATPase activity, gastric wall mucous in EtOH-induced ulcer, and gastric secretion parameters were estimated in the PL-induced ulcer model.Results: CALE exhibited significant (p < 0.01) dose-dependent inhibition of ulcer index in ASP 12.90–51.61%, EtOH 11.97–40.35%, PL 28.63–63.92%, and CRS 38.30–66.37%, respectively. A significant (p < 0.001) decrease occurred in the level...