Functions and the regulation of cytokines and growth factors in the thrombotic event of arteries and veins

: Recent progress of molecular biology has elicited the pathogenesis of arterial and venous thrombosis at the cellular level. The pathogenesis, as well as the etiology of the sequelae, has become clear to be closely relevant to inflammatory cytokines and growth factors such as tumor recrosis factor (TNF) alpha, interleukin-1 beta, or vascular endothelial growth factor (VEGF). From this point of view, the anti-cytokine or the anti-growth factor therapy including the use of some proteins, antibodies, drugs, and gene delivery systems has every possibility of improving the therapeutic outcome for the thrombosis.