A video-based, personalized web page (VBPWP) as a complement to clinical trial (CT) patient management.

266Background: Most advances in the diagnosis and treatment (Tx) of patients (pts) with genitourinary (GU) cancers are the result of pt involvement in CTs. There is a clear need to identify ways to improve CT processes for pts and research teams (RTs). The goal of this project is to assess the use of a VBPWP to improve pt compliance, safety, CT quality, and RT efficiency in GU CTs of oral agents. Methods: This is an unblinded, randomized trial using a VBPWP as an intervention (INT) for pts with advanced non-metastatic (M0) or metastatic (M1) GU cancers. Pts consented but not yet started on CTs of oral agents are randomized 2:1 to the INT or control arm. The INT includes videos of provider-pt encounters and educational videos related to dosing and adverse events (AEs). Target accrual is 99 pts. The primary end point is number of cumulative pt violations (PVs) over 4 cycles (4Cs) of INT. PVs are defined as improper dosing, non-compliance, and failure to report AEs or hospitalizations. Herein we report an ea...