Autoantibodies against alpha1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation

Objective To investigate the effects of autoantibodies againstα_adrenergic receptor on cardiac remodeling in patients with hypertension. Methods Five hundred and fifty three patients with hypertension in our hospital were selected. The autoantibodies againstα1 adrenergic receptor in sera of donor were detected by ELISA, and the results of echocardiography were recorded. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension. Results The percentage of autoantibodies againstα1 adrenergic receptor positive was 32. 3% (179/553 ). There were significant difference between the positive group and negative group on the ratio of left atrial enlargement (53.6% , 44.3% , respectively;P0.05) and left ventricular enlargement (12.8%, 6.1% , respectively; P0.01). The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate (HR) and autoantibodies againstα1 adrenergic receptor in the serum (all P 0.05). Conclusions The autoantibodies againstα1 adrenergic receptor have a relationship with left ventricular enlargement of hypertension. Patients with the activity of autoantibodies againstα1 adrenergic might contribute to predict cardiac remodeling.