First Total Synthesis of Murrastifoline B and an Improved Route to Murrastifoline F

We report the first total synthesis of murrastifoline B and an improved route to murrastifoline F using a twofold palladium-catalyzed Buchwald–Hartwig amination as key step. The mono­meric carbazole and the biaryl precursor are also prepared via ­palladium-catalyzed coupling reactions.