Proteomic analysis of the hyaloid vascular system regression during ocular development.
2008
We describe a simple proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and anti-angiogenic factors involved in the hyaloid vascular system regression. Differentially-expressed proteins were identified using twodimensional gel electrophoresis followed by nano-flow chromatography coupled to tandem mass spectrometry. These proteins are expected to provide insight as to their function in the early maintenance and eventual regression of the hyaloid vascular system.
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