Proteomic analysis of the hyaloid vascular system regression during ocular development.

We describe a simple proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and anti-angiogenic factors involved in the hyaloid vascular system regression. Differentially-expressed proteins were identified using twodimensional gel electrophoresis followed by nano-flow chromatography coupled to tandem mass spectrometry. These proteins are expected to provide insight as to their function in the early maintenance and eventual regression of the hyaloid vascular system.