Abstract 19213: Burden of Premature Ventricular Complexes on Routine Holter Monitoring is a Predictor of Ventricular Arrhythmias in Hypertrophic Cardiomyopathy

Nonsustained ventricular tachycardia (NSVT) is a well-established risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM), but the predictive value of premature ventricular complex (PVC) burden is unknown. The objective of this study was to assess correlates and prognostic value of PVC burden for ventricular arrhythmias in HCM. Hypothesis: High PVC burden correlates with NSVT, and is an independent predictor of ventricular arrhythmic events. Methods/Results: Holter data were extracted from 453 HCM patients enrolled in our institutional registry. Seventy-four patients (16%) had NSVT detected on their initial Holter monitors. A total of 27 patients (6%) experienced the composite outcome of SCD, aborted sudden cardiac arrest, ventricular tachycardia, and/or ventricular fibrillation, including appropriate defibrillator shocks. Patients with NSVT have higher PVC burden (Mean: 81.15 PVCs/hr, 95% CI: 37.97-124.34, p=<0.05) compared to patients without NSVT (Mean: 9.01 PVCs/hr, 95% CI: 5.1...