Analysis of Transfusion-Related Acute Lung Injury and Possible Transfusion-Related Acute Lung Injury Reported to the French Hemovigilance Network From 2007 to 2013

Abstract Using the French Hemovigilance Network database from 2007 to 2013, we provide information on demographics, incidence, and risk factors of reported TRALI and possible TRALI; analyse TRALI mitigation efforts for fresh frozen plasma and platelet concentrates; and consider the impact of platelet additive solutions on TRALI incidence. We applied the Toronto consensus conference definitions for TRALI and possible TRALI. Two TRALI subgroups were considered: "Antibody positive" when a donor has HLA (class I or II) and/or HNA antibodies and the recipient has cognate antigen, and "Antibody negative" when immunological investigation is negative or not done. The analysis targeted 378 cases, dividing into antibody positive TRALI (n=75), antibody negative TRALI (n=100), and possible TRALI (n=203). TRALI patients were younger and received more blood components than the general population of transfused patients. Moreover, we identified the following clinical conditions where patients seemed to be at higher risk to develop TRALI: post-partum hemorrhage, acute myeloid leukemia, liver transplantation, allogeneic and autologous hematopoietic stem cells transplantation, polytrauma and thrombotic micro-angiopathy. Policy measures intended to reduce antibody positive TRALI were found effective for apheresis platelet concentrates and fresh frozen plasma, but not for whole blood derived platelet concentrates. The use of platelet additive solutions was associated with a significant reduction in the incidence of TRALI following transfusion of buffy-coat derived platelet concentrates, but not following transfusion of apheresis platelets. Our data reinforce the concept that possible TRALI and TRALI, as defined in the Canadian consensus conference, share many characteristics. No specific policy measures are currently directed at mitigation of possible TRALI despite its impact on transfusion safety. Despite TRALI mitigation measures, the overall incidence of TRALI cases reported to the French Hemovigilance system was not significantly reduced. Therefore, additional research is needed to reduce, if not eradicate all TRALI categories.