Clinical Study on Treatment of Chronic Severe Intrahepatic Cholestatic Hepatitis with Liu Xi Decoction

Objective: Chronic severe intrahepatic cholestasis hepatitis is a clinical refractory disease. We have achieved good results in the treatment of chronic severe intrahepatic cholestasis hepatitis with Liu Chen Tang. This study aims to explore the clinical efficacy of Liu Chen Tang in the treatment of chronic severe intrahepatic cholestasis hepatitis. Methods: Thirty-five patients with chronic severe intrahepatic cholestatic hepatitis were randomly divided into Chinese medicine treatment group (n=23) and control group (n=12). The changes of symptoms, signs such as yellow eyes and body, fatigue, nausea, low food intake, and yellow urine and liver function including serum total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), γ-glutamyl peptide transferase (GGT), before and after treatment were observed. Results: The improvement of the above indicators in the treatment group was significantly better than that of the control group (P<0.01 or P<0.05). The effective rate of the treatment group was 95.6%, and the effective rate of the control group was 58.3%. Conclusion: Through the application of Liu Xi Decoction in the treatment of chronic severe intrahepatic cholestatic hepatitis, it was observed that the treatment group was significantly better than the control group. Liu Xi Decoction is an effective prescription for the treatment of chronic severe intrahepatic cholestatic hepatitis and is worthy of further popularization and application.