Genomic Imprinting in Turner Syndrome: Effects on Response to Growth Hormone and on Risk of Sensorineural Hearing Loss

0.001; X maternal :r 0.535, P 0.001) and with mother’s height (all: r 0.510, P 0.001; X maternal :r 0.574, P 0.001) but only weakly with father’s height (all: r 0.334, P 0.015; X maternal :r 0.292, P 0.094). Using a linear model including age and height at GH initiation,subjectswithX maternal hadagreatermeanheightgainthanthose with X paternal (SD score difference and 95% confidence interval for all karyotypes was 0.43 and 0.04–0.82, P 0.030, and for 45,X was 0.64 and 0.06–1.21, P 0.031); X-linked imprinting explained 36– 53% of the GH response. After pure tone audiometry testing, X maternal subjects were also less likely (P 0.040) to have sensorineural hearing loss than X paternal subjects.