Effect of TCM Treatment with Principle of Supplementing-Qi Nourishing-Yin and Activating Blood Circulation on Nitric Oxide in Patients with Early-stage Diabetic Nephropathy

To observe the clinical effect of the therapeutic principle of supplementing-Qi nourishing-Yin and activating blood circulation (SNA) on nitric oxide (NO) level in patients with early stage diabetic nephropa-thy (DN). Methods: Patients with DN were randomly divided into two groups, 31 in the control group and 34 in the treated group. Training on awareness of diabetes, conventional hypoglycemic and symptomatic treatment were given to the patients in the control group, to the patients in the treated group, mainly the treatment of SNA was given additionally. Results: After 8 weeks treatment, the clinical symptom scores of DN lowered, the urinary albumin excretion/24 hrs and NO level decreased significantly in the treated group, as compared with the control group, the difference was significant (P0.05 or P0.01), while the decrease of NO level in the control group after treatment was insignificant. Conclusion: The high production of NO in early stage DN is related with the glomerular hyperfiltration, SNA treatment could improve the glomerular hyperfiltration through decreasing the NO level in kidney.