The importance of time: Time delays in acute stroke

Abstract Background Endovascular treatment (EVT) of severe acute ischemic stroke (AIS) determined by large vessel occlusion (LVO) is effective and safe. Debate still goes on especially about time importance and utilization of advanced penumbra imaging at the expense of loosing valuable minutes. Methods We did a meta-analysis focused on time of randomized clinical trials (RCTs) that started to use methodically the new-tech stent retrievers. The chosen time interval was onset-groin time (from last seen well to sheath insertion in the cathlab). Primary outcome was good functional outcome (mRS of 0–2) at 90 days, and secondary outcomes were mortality at 90 days and symptomatic intra-cerebral hemorrhage (sICH). Furthermore, we did a sub-analysis of the EVT patients to find a correlation between faster times and outcomes. We did the same sub-analysis including also single-arm registries that used modern stent retrievers. Results Totally data from 1287 patients (5 RCTs) were analyzed, whose 634 EVT patients were divided into two groups based on time (faster/slower than 240 min). Furthermore 1501 EVT-treated patients (9 studies) were divided into two pre-specified groups (fast/slow) and analyzed. In both meta-analysis and sub-analysis, the fast group had better functional outcome at 90 days [log OR = −2.07, 95% CI (−3.00, −1.14)] and less deaths [log OR = −0.56, 95% CI (−3.66, −2.55)], demonstrating that onset-groin time has a strong impact even on mortality. On the other hand, sICH resulted to be more frequent in the slow group [log OR = 0.18, 95% CI (−1.36, −1.71)] emphasizing how delays could even worsen AIS. Conclusions This meta-analysis supports the “Time is brain” strategy in treatment of acute ischemic stroke. In general, fast endovascular treatment (groin puncture within