In vivo skin chromophore mapping using a multimode imaging dermoscope (SkinSpect
2013
We introduce a multimode dermoscope (SkinSpect TM ) we developed for early detection of
melanoma by combining fluorescence, polarization and hyperspectral imaging. Acquired reflection
image datacubes were input to a wavelength-dependent linear model to extract the relative
contributions of skin chromophores at every pixel. The oxy-hemoglobin, deoxy hemoglobin,
melanin concentrations, and hemoglobin oxygen saturation by the single step linear least square
fitting and Kubelka-Munk tissue model using cross polarization data cubes were presented. The
comprehensive data obtained by SkinSpect can be utilized to improve the accuracy of skin
chromophore decomposition algorithm with less computation cost. As an example in this work, the
deoxy-hemoglobin over-estimation error in highly pigmented lesion due to melanin and deoxy
hemoglobin spectral cross talk were analyzed and corrected using two-step linear least square fitting
procedure at different wavelength ranges. The proposed method also tested in skin with underlying
vein area for validating the proof of concept.
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