AB1312 Effects of vitamin d on disease activity, functional disability and serum interleukin-6 in rheumatoid arthritis

Background Vitamin D may have a potential role in rheumatoid arthritis (RA) pathogenesis by inhibiting the expression of pro-inflammatory cytokines including interleukin-6 (IL-6) 1–2 . Objectives The aim of this study is to determine the clinical factors of vitamin D deficiency in a multi-ethnic Malaysian RA patients and its association with disease activity, functional disability and serum IL-6 level. Methods One-hundred RA patients and 50 healthy controls, age- and sex-matched were recruited. DAS28 and HAQ score were assessed. Baseline serum vitamin D and IL-6 were measured in all subjects. RA patients who were vitamin D deficient were given loading dose of vitamin D3 and repeated assessments were done. Results Vitamin D deficiency ( Conclusions Vitamin D deficiency is prevalent in Malaysian RA patients. This study suggests that vitamin D does not have a role in disease activity or serum IL-6 but it may have a role in functional disability in RA patients. References [1] van Hamburg JP, et al.TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation. Ann Rheum Dis,2012.71(4):606–12 [2] Wen H, et al. 1,25 (OH) 2-Vitamin-D3 attenuates Th17-related cytokines expression in peripheral blood mononuclear cells in patients with early-diagnosed rheumatoid arthritis. Zhonghua nei ke za zhi,2015.54(4):317–21 Acknowledgements We thank Arthritis Foundation Malaysia for the financial support of this study. Disclosure of Interest None declared