Biologics in dermatology

The role of biologicals in dermatology has seen an exponential growth in the last few years. Biologicals such as TNF-alpha inhibitors have now lost their novelty and are routinely used all over the world. As the pathogenesis of various diseases is now being understood better, we have been able to create more targeted biological therapies for a number of dermatological conditions. We attempt to compile an update on the newer biologicals in use today, and briefly touch upon the older ones as well. We conducted an extensive literature search and have covered TNF-alpha inhibitors, molecules against T cell receptors, Janus Kinase inhibitors, interleukin based molecules, fusion proteins, and some newer biologicals as well. Their mechanisms of action, indications and dosage have been covered in our review.