Portal Chronic Inflammation in Nonalcoholic Fatty Liver Disease: An Histologic Marker of Advanced NAFLD Clinicopathologic Correlations from the NASH Clinical Research Network

Untreated adult nonalcoholic fatty liver disease (NAFLD) is characterized by absent or mild portal chronic inflammation (CI); in the portal-based pediatric pattern of NAFLD, portal CI may be a predominant component. This study was undertaken to correlate clinical features with portal CI in the subjects enrolled in the NASH CRN. Methods Histology from central grading and clinical parameters temporally related to the biopsy were evaluated from 728 adults and 205 children.