Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High-fat Diet-fed Mice.

SCOPE Current evidence supports the beneficial effect of polyphenols on the management of obesity and associated comorbidities. This is the case for propolis, a polyphenol-rich substance produced by bees. The aim of the present study was to evaluate the effect of a poplar propolis ethanolic extract (PPEE) on obesity and glucose homeostasis, and to unveil its putative molecular mechanisms of action. METHODS AND RESULTS Male high-fat (HF) diet-fed mice were administered PPEE for 12 weeks. CONCLUSION PPEE supplementation may represent an interesting preventive strategy to tackle the onset of obesity and associated metabolic disorders. This article is protected by copyright. All rights reserved.