Spirocyclizative Remote Arylcarboxylation of Non-Activated Arenes with CO2 via Visible-Light-Induced Reductive Dearomatization
2021
Visible-light-induced reductive dearomatization of
non-activated arenes is a very challenging transformation and remains in its
infancy. Herein, we report a novel strategy to achieve a visible-light-induced
spirocyclizative remote arylcarboxylation of non-activated arenes including
naphthalenyl- and phenyl-bearing aromatics with CO2 under mild
conditions through a radical-polar crossover cascade (RPCC). This reductive
dearomatization protocol rapidly delivers a broad range of spirocyclic and
valuable carboxylic acid derivatives from readily accessible aromatic
precursors with generally good regioselectivity and chemoselectivity.
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