Using mixtures of biological samples as genome-scale process controls

9 10 Abstract: 11 12 Background: 13 14 Genome-scale "-omics" measurements are challenging to benchmark due to the enormous variety 15 of unique biological molecules involved. Mixtures of previously-characterized samples can be 16 used to benchmark repeatability and reproducibility using component proportions as truth for the 17 measurement. We describe and evaluate experiments characterizing the performance of RNA-