Effect of 24R,25-dihydroxyvitamin D3 in experimental diabetic rats.

The results are presented of a controlled study in male Wistar rats into the effects of 24R,25-dihydroxyvitamin 0 3 on blood glucose levels, bone calcium content and AOP-induced platelet aggregation in streptozocin-induced diabetes mellitus. Blood glucose levels were shown to be decreased by 10 lAg/kg 24R,25-dihydroxyvitamin 0 3, The reduced bone calcium content associated with diabetes mellitus was returned to normal levels with both 1 and 10 lAg/kg 24R,25-dihydroxyvitamin 0 3• It was also shown to exhibit dose­ dependent anti-platelet activity. The data suggest that 24R,25-dihydroxyvitamin 0 3 might have potential as a mild therapeutic agent in the treatment of osteoporosis and platelet hyperactivity associated with diabetes mellitus.