The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

Pedro A. Mateos-Gomez,Tatiana Kent,Sarah K Deng,Shane McDevitt,Ekaterina Kashkina,Trung M. Hoang,Richard T. Pomerantz,Agnel Sfeir

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

2017

Pedro A. Mateos-Gomez
Tatiana Kent
Sarah K Deng
Shane McDevitt
Ekaterina Kashkina
Trung M. Hoang
Richard T. Pomerantz
Agnel Sfeir

Biochemical and cellular analyses reveal that the helicase activity of DNA polymerase theta (Polθ) antagonizes RPA to promote DNA strand annealing and double-strand break repair via alt-NHEJ in mouse ES cells.

Keywords:

DNA
Molecular biology
Helicase activity
Helicase
DNA Polymerase Theta
Biology
Embryonic stem cell
Non-homologous end joining
Gene targeting
Homologous recombination
Polymerase
DNA repair

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