Three new abietane-type diterpene glycosides from the roots of Tripterygium wilfordii

Abstract Three new abietane-type diterpene glycosides named as tripterycoside A ( 1 ), tripterycoside B ( 2 ), tripterycoside C ( 3 ), along with two known ones, 11-O-β- d -glucopyranosyl-neotritophenolide ( 4 ), wilfordoside A ( 5 ), and nine other known compounds, 5-hydroxymethylmellein ( 6 ),1,2-bis-(3-methoxy-4-hydroxyphenyl)-1,3-propanediol ( 7 ), leptolepisol C ( 8 ), icariol A 2 ( 9 ), tripfordine A ( 10 ), 16α-hydroxy-ent-kauran-19-oic acid ( 11 ),wilforine ( 12 ), wilfordine ( 13 ), 3-acetyloleanolic acid ( 14 ),were isolated from the roots of Tripterygium wilfordii . Their structures have been elucidated on the basis of NMR and MS data. To the best of our knowledge, abietane-type diterpene glycosides were rarely reported natural products, especially abietane-type diterpene glycoside containing 7-oxo group (compound 3 ) was reported here for the first time. Furthermore, compounds 6 , 7 , 8 and 14 were isolated from this plant for the first time. Compounds 1 – 5 showed statistically significant inhibitory effects on IL-1β secretion in LPS-induced rat primary synovial fibroblasts at 10 μM.