Prevention of Aspirin-Induced Gastric Ulceration in Rats by α-Methyldopa and Disulfiram

Aspirin at the dose of 200 mg/kg, administered orally, produced gastric mucosal ulceration in 100% of rats after 4 h. Pretreatment of animals with α-methyldopa at the doses of 25 and 50 mg/kg and/or d