Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.

Xuejuan Jiang,J. Esteban Castelao,David J. Vandenberg,Angel Carracedo,Carmen M. Redondo,David V. Conti,Jesús P. Paredes-Cotoré,John D. Potter,Polly A. Newcomb,Michael N. Passarelli,Mark A. Jenkins,John L. Hopper,Steven Gallinger,Loic Le Marchand,Maria Elena Martinez,Dennis J. Ahnen,John A. Baron,Noralane Morey Lindor,Robert W. Haile,Manuela Gago-Dominguez

Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.

2013

Background Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry.

Keywords:

Single-nucleotide polymorphism
Ulcerative colitis
Epidemiology of cancer
Locus (genetics)
Colorectal cancer
Genetic variation
Genome-wide association study
Cancer research
Medicine
Pathology
Case-control study
Odds ratio
Bioinformatics

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