Substitutions at residue 211 in the prion protein drive a switch between CJD and GSS syndrome, a new mechanism governing inherited neurodegenerative disorders

Katell Peoc’h1,2,3, Etienne Levavasseur3,4,5,6, Emilien Delmont7, Alfonso De Simone8, Isabelle Laffont-Proust3,4,5,6, Nicolas Privat3,4,5,6, Yassmine Chebaro9, Celine Chapuis10, Pierre Bedoucha7, Jean-Philippe Brandel3,4,5,6,11, Annie Laquerriere12, Jean-Louis Kemeny13, Jean-Jacques Hauw3,4,5,6,14, Michel Borg15, Human Rezaei10, Philippe Derreumaux9, Jean-Louis Laplanche1,2,3 and Stephane Haik3,4,5,6,11,14,∗