α-Methyldopa for climacteric hot flushes: a double-blind, randomized, cross-over study

The effects of single evening doses of α-methyldopa and placebo have been compared in 40 women with climacteric hot flushes. the study was designed as a double-blind, randomized and cross-over investigation. of the 24 patients who completed the study, 15 reported that they preferred the α-methyldopa treatment (p 0.05). It is concluded that α-methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.