Interrelationship of pseudouridine and transfer RNA metabolic disorders in thermal injury

Excretion and turnover rate of radioactive pseudouridine were studied in intact and burned rats. The thermic injury increased the pseudouridine excretion and lowered the rate of decrease in its specific radioactivity. Relative increase in excretion of pseudouridine was more distinct for the "B" isomer as compared with the isomer "C". The general pattern of dynamics of alterations in pseudouridine turnover after thermic injury corresponded to the patterns of impairments in metabolism of transfer RNA, which were studied previously. But the rate of pseudouridine turnover considerably exceeded the rate of tRNA metabolism either in normal state or in thermic injury. Language: ru