Cumulus cells microRNA expression when LH is added to controlled ovarian stimulation protocol: a pilot study

ABSTRACT Research Question: Recombinant FSH administration in controlled ovarian stimulation for in vitro fertilization (IVF) is a standard procedure, while the role of LH is controversial. MicroRNAs participate in the regulation of gene expression of gonadotrophin functions. We aimed to study the possible role of miRNAs in ovarian follicular development in groups having different ovarian stimulation protocols. We aimed to identify miRNA expression in cumulus cells of infertile women undergoing IVF by comparing two distinct protocols; to study if there are different miRNA expression profiles in these protocols, and to analyse the regulated pathways. Design: This prospective observational study included 13 patients following the inclusion criteria: