Effects of hydrogen sulfide on the ethology of rats with formalin-induced inflammatory pain

Objectives To evaluate the effect of intrathecal pretreatment of sodium hydrosulfide(NaHS)-hydrogen sulfide donor and intraperitoneal injection of cystathionine-γ-liase inhibitor PAG on the ethology of rat with formalin-induced inflammatory pain,and to explore the role of hydrogen sulfide,a small-molecule gas in inflammatory pain.Methods There were no significant statistical differences in the scores of pain-induced ethology between the pain model group,ACSF group and the solvent group(P0.05).In the second phase of response,there were no significant statistical differences in the scores of pain-induced ethology in ACSF group and the normal saline group,as compared to the pain model group(P0.05),while those in NaHS group and PAG group showed a significant decrease(P0.05).Results Control group and solvent group of pain behavioral score had no significant statistical difference(P0.05).In the second period,compared to control group,rat pain behavior scores in ACSF group and saline group had no significant statistical difference(P0.05),but that of NaHS group and PAG group reduced significantly(P0.05).Conclusion Both intrathecal injection of NaHS and intraperitoneal injection of PAG could produce anti-nociceptive effects.