Clinical Efficacy of Concurrent Docetaxel with 3D-CRT for Locally Advanced NSCLC

Objective To evaluate the clinical efficacy,mechanism and tolerance of concurrent Docetaxel with three-dimensional conformal radiation therapy(3D-CRT) in treating patients with locally advanced NSCLC.Methods Sixty untreated cases who had been pathologically confirmed as squamous cell carcinoma(stage III A-III B),were randomly divided into observation group and control group,30 cases for each.The observation group received 3D-CRT concurrently with weekly Docetaxel(36 mg/m2) for six weeks,after the completion of 3D-CRT,TP regimen was given for 3 cycles.The control group received 4-6 cycles of TP regimen after the completion of 3D-CRT.Results For short-term effect(CR+PR),it was 80% and 66.7% in the observation group and control group respectively.The 1-,2-,and 3-year loco-regional control rates were 90.0%,80.0% and 70.0% respectively in the observation group,and 80.0%,53.0% and 40.0% in the control group.The patients could tolerate the above adverse reactions well after receiving symptomatic treatment.Conclusion It is found that observation group is superior to the controls in short-term effect,2-and 3-year loco-regional control rate and survival rate(P0.05).Therefore,concurrent Docetaxel with 3D-CRT is effective for locally advanced NSCLC and well tolerated,which is worthy of clinical application.