FRI0393 Predictive value of history of digital ulcers in a eustar cohort of patients with systemic sclerosis
2013
Background Digital ulcers (DUs) have a prevalence of up to 36% in systemic sclerosis (SSc) patients and are a heavy burden, significantly reducing quality of life and function and leading to severe complications. Objectives To evaluate in SSc patients the hypothesis that a history of DUs at presentation may be a predictor of vascular outcomes and of overall clinical worsening and death. Methods All patients from the EUSTAR database (MEDS online), satisfying the 1980 ACR classification criteria for SSc, who had a follow-up of at least 3 years since inclusion or who have died, were included in the analysis. History of DUs at presentation as a predictor of disease progression or death was evaluated by univariate and multivariate Cox proportional hazard regression analysis. Results 3207 patients matched the inclusion criteria (age at inclusion 54.6±13.6 years, disease duration since the onset of first non-Raynaud’s symptom: 8.1±7.7 years and from onset of Raynaud’s phenomenon (RP) 12.3±11.2 years, male sex 13.2%, 33.4% diffuse subset, 96.4% presenting RP). At presentation, 1092 patients had a history of DUs (34.1%). DU history at baseline was the strongest predictor for the presence of active DUs at prospective visits, with a hazard ratio (HR, 95% confidence interval) of 2.55 (2.02-3.20), p There were 453 deaths recorded. The mean±SD time to death since RP onset was 17.3±11.3 years and since first non-Raynaud symptom 8.9±8.6 years. DUs were found to be predictive for death (HR 1.50,(1.15-1.96), p Conclusions A history of DUs at presentation is a predictor for the presence of DUs at follow-up and forecasts early mortality in patients with SSc. As such, the presence of DUs in a patient with SSc predicts a poor outcome. Disclosure of Interest : None Declared
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